What's the difference?

If you don't already have a preference, then it doesn't really matter where your website is hosted. The reason we offer the option is because some companies and organizations have a mandate to host their data in Canada or prefer to host their site in Canada for data privacy or marketing reasons.

A good guideline might be that if your business targets a Canadian market, host your website in Canada. If your business targets a US market, host it in the US.